Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Khoa h\u1ecdc t\u1ef1 nhi\u00ean l\u00e0 n\u01a1i t\u1eadp trung c\u00e1c PTN v\u00e0 c\u00e1c B\u1ed9 m\u00f4n th\u1ef1c hi\u1ec7n c\u00e1c h\u01b0\u1edbng nghi\u00ean c\u1ee9u c\u01a1 b\u1ea3n v\u00e0 \u1ee9ng d\u1ee5ng kh\u00e1c nhau, n\u01a1i c\u00f3 nhi\u1ec1u ti\u1ec1m n\u0103ng ph\u00e1t tri\u1ec3n c\u00e1c \u0111\u1ec1 t\u00e0i nghi\u00ean c\u1ee9u \u1ee9ng d\u1ee5ng li\u00ean ng\u00e0nh. PTN C\u00f4ng ngh\u1ec7 sinh h\u1ecdc ph\u00e2n t\u1eed, PTN ph\u00e2n t\u00edch trung t\u00e2m, PTN nghi\u00ean c\u1ee9u v\u00e0 \u1ee9ng d\u1ee5ng t\u1ebf b\u00e0o g\u1ed1c, PTN v\u1eadt li\u1ec7u k\u1ef9 thu\u1eadt cao, … c\u00f3 th\u1ec3 h\u1ee3p t\u00e1c \u0111\u1ec3 ph\u00e1t tri\u1ec3n s\u1ea3n ph\u1ea9m c\u00f3 gi\u00e1 tr\u1ecb t\u1eeb vi\u1ec7c nghi\u00ean c\u1ee9u t\u1ea1o c\u00e1c ph\u00e2n t\u1eed sinh h\u1ecdc, ph\u00e2n t\u00edch v\u00e0 kh\u1ea3o s\u00e1t th\u1eed nghi\u1ec7m ho\u1ea1t t\u00ednh, \u0111\u1ebfn s\u1ea3n xu\u1ea5t c\u00e1c s\u1ea3n ph\u1ea9m th\u1ee9 c\u1ea5p c\u00f3 gi\u00e1 tr\u1ecb ph\u1ee5c v\u1ee5 cho c\u1ed9ng \u0111\u1ed3ng. Trung t\u00e2m Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 sinh h\u1ecdc \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n nh\u1eb1m t\u1eadn d\u1ee5ng c\u00e1c \u01b0u th\u1ebf c\u1ee7a Tr\u01b0\u1eddng v\u1edbi m\u1ee5c ti\u00eau cu\u1ed1i c\u00f9ng l\u00e0 t\u1ea1o ra v\u00e0 chuy\u1ec3n giao c\u00e1c s\u1ea3n ph\u1ea9m \u1ee9ng d\u1ee5ng c\u00f3 gi\u00e1 tr\u1ecb c\u00f4ng ngh\u1ec7 cao trong khu v\u1ef1c v\u00e0 l\u00e0m ti\u1ec1n \u0111\u1ec1 cho c\u00e1c nghi\u00ean c\u1ee9u ti\u1ebfp theo.<\/p>\n\n\n\n
Ho\u1ea1t \u0111\u1ed9ng nghi\u00ean c\u1ee9u c\u1ee7a Trung t\u00e2m d\u1ef1a tr\u00ean s\u1ef1 h\u1ee3p t\u00e1c ch\u1eb7t ch\u1ebd v\u1edbi PTN C\u00f4ng ngh\u1ec7 Sinh h\u1ecdc ph\u00e2n t\u1eed v\u00e0 c\u00e1c B\u1ed9 m\u00f4n c\u1ee7a Khoa Sinh h\u1ecdc, Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Khoa h\u1ecdc t\u1ef1 nhi\u00ean. Trung t\u00e2m \u0111\u1ea3m nh\u1eadn vi\u1ec7c nghi\u00ean c\u1ee9u s\u1ea3n xu\u1ea5t c\u00e1c ph\u00e2n t\u1eed sinh h\u1ecdc\/c\u00f3 ho\u1ea1t t\u00ednh sinh h\u1ecdc s\u1eed d\u1ee5ng c\u00e1c ph\u01b0\u01a1ng ph\u00e1p Sinh h\u1ecdc ph\u00e2n t\u1eed v\u00e0 h\u00f3a h\u1ecdc ph\u1ee5c v\u1ee5 cho nghi\u00ean c\u1ee9u c\u01a1 b\u1ea3n v\u00e0 \u1ee9ng d\u1ee5ng.<\/p>\n\n\n\n\n\n\n\n
H\u01b0\u1edbng nghi\u00ean c\u1ee9u n\u00e0y do TS. Phan Th\u1ecb Ph\u01b0\u1ee3ng Trang c\u00f9ng v\u1edbi GS.Wolfgang Schumann \u0111\u1ea3m tr\u00e1ch. C\u00e1c nghi\u00ean c\u1ee9u ch\u1ee7 y\u1ebfu t\u1eadp trung v\u00e0o vi\u1ec7c khai th\u00e1c c\u01a1 s\u1edf d\u1eef li\u1ec7u (ph\u1ed1i h\u1ee3p v\u1edbi h\u01b0\u1edbng Tin \u2013 Sinh h\u1ecdc), c\u00e1c th\u00f4ng tin nghi\u00ean c\u1ee9u th\u1ef1c nghi\u1ec7m v\u1ec1 s\u1ef1 \u0111i\u1ec1u h\u00f2a bi\u1ec3u hi\u1ec7n gen. C\u00e1c h\u1ec7 th\u1ed1ng vector bi\u1ec3u hi\u1ec7n s\u1ebd \u0111\u01b0\u1ee3c x\u00e2y d\u1ef1ng d\u1ef1a tr\u00ean c\u00e1c th\u00f4ng tin n\u00e0y v\u1edbi m\u1ee5c ti\u00eau nh\u1eb1m trang b\u1ecb cho c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u th\u00eam m\u1ed9t s\u1ed1 c\u00f4ng c\u1ee5 \u0111\u1ec3 nghi\u00ean c\u1ee9u s\u1ef1 bi\u1ec3u hi\u1ec7n gen tr\u00ean\/ trong B. subtilis. Ngo\u00e0i ra, c\u00e1c vector bi\u1ec3u hi\u1ec7n cho c\u00e1c ch\u1ee7ng ch\u1ee7 kh\u00e1c c\u0169ng \u0111ang d\u1ea7n d\u01b0\u1ee3c ho\u00e0n thi\u1ec7n t\u1ea1i nh\u00f3m nghi\u00ean c\u1ee9u.<\/p>\n\n\n\n\n\n\n\n
H\u01b0\u1edbng nghi\u00ean c\u1ee9u n\u00e0y do TS. Phan Th\u1ecb Ph\u01b0\u1ee3ng Trang ph\u1ee5 tr\u00e1ch ch\u00ednh nh\u1eb1m bi\u1ec3u hi\u1ec7n v\u00e0 t\u00ednh ch\u1ebf c\u00e1c protein\/ enzyme ph\u1ee5c v\u1ee5 cho c\u00e1c nghi\u00ean c\u1ee9u c\u01a1 b\u1ea3n v\u00e0 \u1ee9ng d\u1ee5ng. \u0110\u1ec3 bi\u1ec3u hi\u1ec7n c\u00e1c protein t\u00e1i t\u1ed5 h\u1ee3p, ch\u00fang t\u00f4i s\u1eed d\u1ee5ng c\u00e1c h\u1ec7 th\u1ed1ng bi\u1ec3u hi\u1ec7n cho B. subtilis \u0111\u01b0\u1ee3c t\u1ea1o ra b\u1edfi nh\u00f3m nghi\u00ean c\u1ee9u, hay E. coli v\u00e0 n\u1ea5m men t\u1eeb c\u00e1c vector th\u01b0\u01a1ng m\u1ea1i. Ngo\u00e0i ra, m\u1ed9t h\u01b0\u1edbng nghi\u00ean c\u1ee9u kh\u00e1c c\u1ee7a nh\u00f3m l\u00e0 t\u1ea1o ra c\u00e1c ch\u1ee7ng vi sinh v\u1eadt c\u00f3 ti\u1ec1m bi\u1ec3u hi\u1ec7n cellulase nh\u1eb1m th\u1ee7y ph\u00e2n cellulose. C\u00e1c enzyme \u0111\u01b0\u1ee3c t\u1eadp trung nghi\u00ean c\u1ee9u t\u1eeb Clostridium cellulovorans, Bacillus subtilis, Clostridium thermocellum (v\u00ed d\u1ee5 nh\u01b0 celA, celB, celS v\u00e0 cipA (khung cellulosome)).<\/p>\n\n\n\n\n\n\n\n
H\u01b0\u1edbng nghi\u00ean c\u1ee9u n\u00e0y do TS. Nguy\u1ec5n \u0110\u1ee9c Ho\u00e0ng v\u00e0 TS. Phan Th\u1ecb Ph\u01b0\u1ee3ng Trang tr\u1ef1c ti\u1ebfp ph\u1ee5 tr\u00e1ch nh\u1eb1m kh\u00e1m ph\u00e1 c\u00e1c peptide\/ protein c\u00f3 \u00e1i l\u1ef1c v\u1edbi protein m\u1ee5c ti\u00eau. \u0110\u00e2y l\u00e0 h\u01b0\u1edbng nghi\u00ean c\u1ee9u th\u1ef1c hi\u1ec7n d\u1ef1a tr\u00ean c\u00e1c h\u1ee3p t\u00e1c v\u1edbi (i) GS.Phan Anh Tu\u1ea5n, \u0110H Nanyang \u0111\u1ec3 t\u00ecm hi\u1ec3u v\u1ec1 c\u00e1c peptide g\u1eafn l\u00ean G-Quadruplex ng\u01b0\u1eddi c\u00f3 li\u00ean quan \u0111\u1ebfn s\u1ef1 ng\u1eafn d\u1ea7n c\u1ee7a telomere. (ii) GS. Luc Brunsveld, \u0110H Eindhoven \u0111\u1ec3 t\u00ecm hi\u1ec3u v\u1ec1 c\u00e1c peptide b\u00e1m l\u00ean c\u00e1c nuclear receptor c\u00f3 li\u00ean quan \u0111\u1ebfn ung th\u01b0 v\u00fa. (iii) GS. Stephan Diekmann, Leibniz Instiute for Age Research \u0111\u1ec3 ph\u00e1t tri\u1ec3n c\u00e1c kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng t\u1ed5ng h\u1ee3p c\u00f3 \u00e1i l\u1ef1c v\u1edbi c\u00e1c protein li\u00ean quan \u0111\u1ebfn kinetochore d\u00f9ng trong nghi\u00ean c\u1ee9u c\u01a1 b\u1ea3n v\u00e0 th\u01b0\u01a1ng m\u1ea1i. C\u00e1c ph\u01b0\u01a1ng ph\u00e1p s\u1eed d\u1ee5ng ch\u00ednh l\u00e0 phage v\u00e0 ribosome display k\u1ebft h\u1ee3p v\u1edbi tinh ch\u1ebf protein d\u00f9ng trong vi\u1ec7c \u0111\u00e1nh gi\u00e1 \u00e1i l\u1ef1c t\u01b0\u01a1ng t\u00e1c gi\u1eefa c\u00e1c ph\u00e2n t\u1eed th\u00f4ng qua c\u00e1c ph\u01b0\u01a1ng ph\u00e1p l\u00fd sinh hay h\u00f3a sinh.<\/p>\n\n\n\n\n\n\n\n
H\u01b0\u1edbng nghi\u00ean c\u1ee9u n\u00e0y do TS. Nguy\u1ec5n \u0110\u1ee9c Ho\u00e0ng ph\u1ee5 tr\u00e1ch. Thu\u1eadt ng\u1eef Microbiorobot d\u00f9ng \u0111\u1ec3 ch\u1ec9 nh\u1eefng vi sinh v\u1eadt t\u00e1i t\u1ed5 h\u1ee3p an to\u00e0n, c\u00f3 kh\u1ea3 n\u0103ng x\u00e2m nh\u1eadp v\u00e0o c\u01a1 th\u1ec3 \u0111\u1ed9ng v\u1eadt \u1edf nh\u1eefng v\u1ecb tr\u00ed chuy\u00ean bi\u1ec7t v\u00e0 c\u00f3 kh\u1ea3 n\u0103ng cung c\u1ea5p c\u00e1c t\u00e1c nh\u00e2n tr\u1ecb li\u1ec7u m\u1ed9t c\u00e1ch ch\u1ee7 \u0111\u1ed9ng theo \u00fd mu\u1ed1n c\u1ee7a con ng\u01b0\u1eddi th\u00f4ng qua vi\u1ec7c ki\u1ec3m so\u00e1t c\u00e1c t\u00e1c nh\u00e2n c\u1ea3m \u1ee9ng. Microbiorobot l\u00e0 m\u1ed9t h\u01b0\u1edbng nghi\u00ean c\u1ee9u m\u1edbi mang nhi\u1ec1u ti\u1ec1m n\u0103ng \u1ee9ng d\u1ee5ng to l\u1edbn trong l\u0129nh v\u1ef1c y h\u1ecdc hi\u1ec7n \u0111\u1ea1i, nh\u01b0 d\u00f9ng l\u00e0m t\u00e1c nh\u00e2n ph\u00e2n ph\u1ed1i vaccine (vaccine delivery vector) hay d\u00f9ng nh\u01b0 m\u1ed9t li\u1ec7u ph\u00e1p tr\u1ecb ung th\u01b0. C\u00e1c ph\u01b0\u01a1ng ph\u00e1p nghi\u00ean c\u1ee9u s\u1eed d\u1ee5ng ch\u00ednh l\u00e0 di truy\u1ec1n h\u1ecdc vi sinh v\u1eadt, c\u00e1c ph\u00e2n t\u00edch v\u1edbi t\u1ebf b\u00e0o \u0111\u1ed9ng v\u1eadt v\u00e0 \u0111\u1ed9ng v\u1eadt.<\/p>\n\n\n\n\n\n\n\n
H\u01b0\u1edbng nghi\u00ean c\u1ee9u n\u00e0y do TS. Nguy\u1ec5n \u0110\u1ee9c Ho\u00e0ng v\u00e0 ThS. V\u00f5 Tr\u00ed Nam ph\u1ee5 tr\u00e1ch, c\u00f9ng c\u1ed9ng t\u00e1c v\u1edbi PGS. TS. Nguy\u1ec5n \u0110\u00ecnh Th\u00fac, ThS. V\u0169 Qu\u1ed1c Ho\u00e0ng, khoa C\u00f4ng ngh\u1ec7 Th\u00f4ng tin v\u00e0 PGS. TS. Ph\u1ea1m Th\u1ebf B\u1ea3o, khoa To\u00e1n \u2013 Tin h\u1ecdc. Nhi\u1ec7m v\u1ee5 ch\u00ednh c\u1ee7a nh\u00f3m l\u00e0 nghi\u00ean c\u1ee9u c\u00e1c ph\u01b0\u01a1ng ph\u00e1p, ph\u00e1t tri\u1ec3n thu\u1eadt to\u00e1n nh\u1eb1m t\u00ecm hi\u1ec3u s\u1ef1 \u0111i\u1ec1u h\u00f2a bi\u1ec3u hi\u1ec7n gen. Ngo\u00e0i ra, nh\u00f3m nghi\u00ean c\u1ee9u c\u00f2n h\u1ed7 tr\u1ee3 c\u00e1c nh\u00f3m ph\u00e1t tri\u1ec3n vector bi\u1ec3u hi\u1ec7n, nghi\u00ean c\u1ee9u s\u1ea3n xu\u1ea5t protein t\u00e1i t\u1ed5 h\u1ee3p v\u00e0 ph\u00e1t tri\u1ec3n microbiorobot.<\/p>\n\n\n\n\n\n\n\n
Nh\u00f3m nghi\u00ean c\u1ee9u do PGS.TS Ng\u00f4 \u0110\u1ea1i Nghi\u1ec7p ph\u1ee5 tr\u00e1ch ch\u00ednh. X\u00e3 h\u1ed9i ng\u00e0y c\u00e0ng ph\u00e1t tri\u1ec3n, c\u00f4ng nghi\u1ec7p h\u00f3a l\u00e0m m\u00f4i tr\u01b0\u1eddng \u00f4 nhi\u1ec5m, \u00e1p l\u1ef1c c\u00f4ng vi\u1ec7c cao,\u2026 \u1ea3nh h\u01b0\u1edfng x\u1ea5u \u0111\u1ebfn s\u1ee9c kh\u1ecfe con ng\u01b0\u1eddi. B\u00ean c\u1ea1nh \u0111\u00f3, cu\u1ed9c s\u1ed1ng ng\u00e0y c\u00e0ng \u0111\u01b0\u1ee3c n\u00e2ng cao, con ng\u01b0\u1eddi c\u00e0ng quan t\u00e2m nhi\u1ec1u \u0111\u1ebfn s\u1ee9c kh\u1ecfe c\u1ee7a ch\u00ednh m\u00ecnh. Do \u0111\u00f3 ng\u01b0\u1eddi ti\u00eau d\u00f9ng r\u1ea5t quan t\u00e2m \u0111\u1ebfn nh\u1eefng s\u1ea3n ph\u1ea9m c\u00f3 ngu\u1ed3n g\u1ed1c t\u1ef1 nhi\u00ean, c\u00f3 ch\u1ee9a c\u00e1c h\u1ee3p ch\u1ea5t c\u00f3 ho\u1ea1t t\u00ednh t\u00ednh sinh h\u1ecdc nh\u01b0 kh\u00e1ng \u00f4xi h\u00f3a, kh\u00e1ng vi\u00eam, kh\u00e1ng ung th\u01b0\u2026. V\u00ec v\u1eady, vi\u1ec7c nghi\u00ean c\u1ee9u c\u00e1c h\u1ee3p ch\u1ea5t c\u00f3 ho\u1ea1t t\u00ednh sinh h\u1ecdc t\u1eeb c\u00e1c ngu\u1ed3n kh\u00e1c nhau, \u0111\u1eb7c bi\u1ec7t c\u00f3 ngu\u1ed3n g\u1ed1c t\u1ef1 nhi\u00ean \u0111ang l\u00e0 xu h\u01b0\u1edbng chung c\u1ee7a x\u00e3 h\u1ed9i, nh\u1eb1m n\u00e2ng cao gi\u00e1 tr\u1ecb s\u1eed d\u1ee5ng s\u1ea3n ph\u1ea9m. M\u1ee5c ti\u00eau c\u1ee7a nh\u00f3m nghi\u00ean c\u1ee9u: (i) Thu nh\u1eadn, t\u00e1ch chi\u1ebft ho\u1eb7c t\u1ed5ng h\u1ee3p c\u00e1c h\u1ee3p ch\u1ea5t c\u00f3 ho\u1ea1t t\u00ednh sinh h\u1ecdc t\u1eeb c\u00e1c ngu\u1ed3n kh\u00e1c nhau. (ii) S\u1eed d\u1ee5ng m\u00f4 h\u00ecnh t\u1ebf b\u00e0o nu\u00f4i c\u1ea5y \u0111\u1ec3 nghi\u00ean c\u1ee9u c\u00e1c h\u1ecdat t\u00ednh kh\u00e1ng oxy h\u00f3a, kh\u00e1ng vi\u00eam v\u00e0 kh\u00e1ng ung th\u01b0 , v\u1ebd ra \u0111\u01b0\u1ee3c con \u0111\u01b0\u1eddng \u1ee9c ch\u1ebf c\u00e1c t\u00edn hi\u1ec7u t\u1ebf b\u00e0o trong c\u00e1c con \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u g\u00e2y stress oxy h\u00f3a, vi\u00eam nhi\u1ec5m v\u00e0 g\u00e2y ung b\u01b0\u1edbu hay ung th\u01b0 di c\u0103n. (iii) T\u1eeb \u0111\u00f3 h\u01b0\u1edbng \u0111\u1ebfn ki\u1ec3m tra tr\u00ean m\u00f4 h\u00ecnh invivo v\u00e0 \u1ee9ng d\u1ee5ng trong ph\u00e1t tri\u1ec3n c\u00e1c s\u1ea3n ph\u1ea9m m\u1ef9 ph\u1ea9m, th\u1ef1c ph\u1ea9m c\u00f3 l\u1ee3i cho s\u1ee9c kh\u1ecfe v\u00e0 c\u00f3 th\u1ec3 l\u00e0 thu\u1ed1c.<\/p>\n\n\n\n\n\n\n\n
C\u00f4ng ngh\u1ec7 sinh h\u1ecdc l\u00e0 m\u1ed9t trong c\u00e1c h\u01b0\u1edbng nghi\u00ean c\u1ee9u \u01b0u ti\u00ean c\u1ee7a Vi\u1ec7t Nam. Vi\u1ec7c ph\u00e1t tri\u1ec3n C\u00f4ng ngh\u1ec7 sinh h\u1ecdc c\u1ea7n c\u00f3 c\u00e1c thi\u1ebft b\u1ecb v\u00e0 v\u1eadt li\u1ec7u s\u1eed d\u1ee5ng ph\u00f9 h\u1ee3p. Tuy nhi\u00ean, hi\u1ec7n nay \u1edf Vi\u1ec7t Nam c\u00e1c thi\u1ebft b\u1ecb v\u00e0 v\u1eadt li\u1ec7u ph\u1ee5c v\u1ee5 c\u00e1c nghi\u00ean c\u1ee9u v\u00e0 \u1ee9ng d\u1ee5ng l\u1ea1i ph\u1ea3i nh\u1eadp ngo\u1ea1i v\u00e0 c\u00f3 gi\u00e1 th\u00e0nh r\u1ea5t cao. Do v\u1eady, vi\u1ec7c nghi\u00ean c\u1ee9u ph\u00e1t tri\u1ec3n c\u00e1c thi\u1ebft b\u1ecb v\u00e0 v\u1eadt li\u1ec7u gi\u00fap l\u00e0m gi\u1ea3m chi ph\u00ed nghi\u00ean c\u1ee9u v\u00e0 \u1ee9ng d\u1ee5ng C\u00f4ng ngh\u1ec7 sinh h\u1ecdc l\u00e0 c\u1ea7n thi\u1ebft. M\u1ee5c ti\u00eau c\u1ee7a c\u1ee7a Trung t\u00e2m trong th\u1eddi gian n\u00e0y l\u00e0 ph\u00e1t tri\u1ec3n c\u00e1c thi\u1ebft b\u1ecb v\u00e0 v\u1eadt li\u1ec7u C\u00f4ng ngh\u1ec7 sinh h\u1ecdc \u0111\u01a1n gi\u1ea3n, c\u00e1c \u0111\u01a1n v\u1ecb nghi\u00ean c\u1ee9u trong n\u01b0\u1edbc ti\u1ebft ki\u1ec7m v\u00e0 ch\u1ee7 \u0111\u1ed9ng h\u01a1n trong vi\u1ec7c s\u1eed d\u1ee5ng thi\u1ebft b\u1ecb v\u00e0 v\u1eadt li\u1ec7u, tr\u00e1nh l\u1ec7 thu\u1ed9c c\u00e1c c\u00f4ng ty n\u01b0\u1edbc ngo\u00e0i.<\/p>\n\n\n\n\n\n\n\n
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