{"id":1371,"date":"2022-04-04T22:18:10","date_gmt":"2022-04-04T15:18:10","guid":{"rendered":"https:\/\/beta.cbbiotec.vn\/?page_id=1371"},"modified":"2025-11-24T12:22:09","modified_gmt":"2025-11-24T05:22:09","slug":"research","status":"publish","type":"page","link":"https:\/\/cbbiotec.vn\/en\/research\/","title":{"rendered":"Research"},"content":{"rendered":"
\"\"<\/figure>\n\n\n\n\n\n\n\n

V\u1ec1 h\u01b0\u1edbng nghi\u00ean c\u1ee9u <\/h2>\n\n\n

Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Khoa h\u1ecdc t\u1ef1 nhi\u00ean l\u00e0 n\u01a1i t\u1eadp trung c\u00e1c PTN v\u00e0 c\u00e1c B\u1ed9 m\u00f4n th\u1ef1c hi\u1ec7n c\u00e1c h\u01b0\u1edbng nghi\u00ean c\u1ee9u c\u01a1 b\u1ea3n v\u00e0 \u1ee9ng d\u1ee5ng kh\u00e1c nhau, n\u01a1i c\u00f3 nhi\u1ec1u ti\u1ec1m n\u0103ng ph\u00e1t tri\u1ec3n c\u00e1c \u0111\u1ec1 t\u00e0i nghi\u00ean c\u1ee9u \u1ee9ng d\u1ee5ng li\u00ean ng\u00e0nh. PTN C\u00f4ng ngh\u1ec7 sinh h\u1ecdc ph\u00e2n t\u1eed, PTN ph\u00e2n t\u00edch trung t\u00e2m, PTN nghi\u00ean c\u1ee9u v\u00e0 \u1ee9ng d\u1ee5ng t\u1ebf b\u00e0o g\u1ed1c, PTN v\u1eadt li\u1ec7u k\u1ef9 thu\u1eadt cao, \u2026 c\u00f3 th\u1ec3 h\u1ee3p t\u00e1c \u0111\u1ec3 ph\u00e1t tri\u1ec3n s\u1ea3n ph\u1ea9m c\u00f3 gi\u00e1 tr\u1ecb t\u1eeb vi\u1ec7c nghi\u00ean c\u1ee9u t\u1ea1o c\u00e1c ph\u00e2n t\u1eed sinh h\u1ecdc, ph\u00e2n t\u00edch v\u00e0 kh\u1ea3o s\u00e1t th\u1eed nghi\u1ec7m ho\u1ea1t t\u00ednh, \u0111\u1ebfn s\u1ea3n xu\u1ea5t c\u00e1c s\u1ea3n ph\u1ea9m th\u1ee9 c\u1ea5p c\u00f3 gi\u00e1 tr\u1ecb ph\u1ee5c v\u1ee5 cho c\u1ed9ng \u0111\u1ed3ng.<\/p>\n

Trung t\u00e2m Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 sinh h\u1ecdc \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n nh\u1eb1m t\u1eadn d\u1ee5ng c\u00e1c \u01b0u th\u1ebf c\u1ee7a Tr\u01b0\u1eddng v\u1edbi m\u1ee5c ti\u00eau cu\u1ed1i c\u00f9ng l\u00e0 t\u1ea1o ra v\u00e0 chuy\u1ec3n giao c\u00e1c s\u1ea3n ph\u1ea9m \u1ee9ng d\u1ee5ng c\u00f3 gi\u00e1 tr\u1ecb c\u00f4ng ngh\u1ec7 cao trong khu v\u1ef1c v\u00e0 l\u00e0m ti\u1ec1n \u0111\u1ec1 cho c\u00e1c nghi\u00ean c\u1ee9u ti\u1ebfp theo. Ho\u1ea1t \u0111\u1ed9ng nghi\u00ean c\u1ee9u c\u1ee7a Trung t\u00e2m d\u1ef1a tr\u00ean s\u1ef1 h\u1ee3p t\u00e1c ch\u1eb7t ch\u1ebd v\u1edbi PTN C\u00f4ng ngh\u1ec7 Sinh h\u1ecdc ph\u00e2n t\u1eed v\u00e0 c\u00e1c B\u1ed9 m\u00f4n c\u1ee7a Khoa Sinh h\u1ecdc, Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Khoa h\u1ecdc t\u1ef1 nhi\u00ean. Trung t\u00e2m \u0111\u1ea3m nh\u1eadn vi\u1ec7c nghi\u00ean c\u1ee9u s\u1ea3n xu\u1ea5t c\u00e1c ph\u00e2n t\u1eed sinh h\u1ecdc\/c\u00f3 ho\u1ea1t t\u00ednh sinh h\u1ecdc s\u1eed d\u1ee5ng c\u00e1c ph\u01b0\u01a1ng ph\u00e1p Sinh h\u1ecdc ph\u00e2n t\u1eed v\u00e0 h\u00f3a h\u1ecdc ph\u1ee5c v\u1ee5 cho nghi\u00ean c\u1ee9u c\u01a1 b\u1ea3n v\u00e0 \u1ee9ng d\u1ee5ng.<\/p>\n\n\n

C\u00e1c h\u01b0\u1edbng nghi\u00ean c\u1ee9u ch\u00ednh<\/h2>\n\n\n\n
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Bacillus subtilis<\/em> \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ph\u1ed5 bi\u1ebfn trong s\u1ea3n xu\u1ea5t enzyme c\u00f4ng nghi\u1ec7p nh\u1edd ba \u0111\u1eb7c \u0111i\u1ec3m n\u1ed5i b\u1eadt l\u00e0 an to\u00e0n, d\u1ec5 nu\u00f4i c\u1ea5y v\u00e0 ti\u1ebft protein hi\u1ec7u qu\u1ea3. \u0110\u1eb7c bi\u1ec7t B. subtilis<\/em> l\u00e0 m\u00f4 h\u00ecnh vi khu\u1ea9n Gram \u00e2m v\u00e0 l\u00e0 nh\u00e0 m\u00e1y t\u1ebf b\u00e0o vi sinh v\u1eadt. Tuy nhi\u00ean, vi\u1ec7c s\u1eed d\u1ee5ng B. subtilis<\/em> cho s\u1ea3n xu\u1ea5t protein t\u00e1i t\u1ed5 h\u1ee3p c\u00f2n r\u1ea5t h\u1ea1n ch\u1ebf m\u00e0 nguy\u00ean nh\u00e2n ch\u1ee7 y\u1ebfu l\u00e0 do kh\u00f4ng c\u00f3 h\u1ec7 th\u1ed1ng bi\u1ec3u hi\u1ec7n m\u1ea1nh th\u00edch h\u1ee3p cho ch\u1ee7ng vi sinh v\u1eadt n\u00e0y. Xu\u1ea5t ph\u00e1t t\u1eeb nhu c\u1ea7u th\u1ef1c t\u1ebf \u0111\u00f3, ch\u00fang t\u00f4i x\u00e2y d\u1ef1ng nh\u00f3m nghi\u00ean c\u1ee9u ph\u00e1t tri\u1ec3n vector bi\u1ec3u hi\u1ec7n. \u0110\u00e2y l\u00e0 h\u01b0\u1edbng nghi\u00ean c\u1ee9u c\u01a1 b\u1ea3n c\u00f3 t\u00ednh \u1ee9ng d\u1ee5ng cao, c\u00f3 kh\u1ea3 n\u0103ng ph\u00e1t tri\u1ec3n c\u00f4ng ngh\u1ec7 n\u1ec1n \u0111\u1ecbnh h\u01b0\u1edbng cho s\u1ef1 ph\u00e1t tri\u1ec3n ng\u00e0nh c\u00f4ng nghi\u1ec7p protein t\u00e1i t\u1ed5 h\u1ee3p trong n\u01b0\u1edbc ….xem th\u00eam.<\/a><\/p>\n

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\"\"<\/figure>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

Tr\u00ean th\u1ebf gi\u1edbi, theo th\u1ed1ng k\u00ea n\u0103m 2016, th\u1ecb tr\u01b0\u1eddng protein t\u00e1i t\u1ed5 h\u1ee3p \u0111\u00e3 \u0111\u1ea1t gi\u00e1 tr\u1ecb 347,2 tri\u1ec7u \u0111\u00f4 la M\u1ef9 v\u00e0 \u01b0\u1edbc t\u00ednh gi\u00e1 tr\u1ecb n\u00e0y s\u1ebd v\u01b0\u1ee3t ng\u01b0\u1ee1ng 593,4 tri\u1ec7u \u0111\u00f4 la M\u1ef9 v\u00e0o n\u0103m 2025. H\u1ea7u h\u1ebft c\u00e1c s\u1ea3n ph\u1ea9m protein t\u00e1i t\u1ed5 h\u1ee3p \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng l\u00e0m d\u01b0\u1ee3c ph\u1ea9m nh\u01b0 G-CSF, Erythropoietin, Interferon, Vaccines\u2026 gi\u00fap ph\u00f2ng ng\u1eeba, ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng, ung th\u01b0, thi\u1ebfu m\u00e1u…xem th\u00eam<\/a><\/p>\n

\"Development<\/p>\n

S\u1eed d\u1ee5ng vaccine l\u00e0 m\u1ed9t c\u00e1ch hi\u1ec7u qu\u1ea3 \u0111\u1ec3 ng\u0103n ng\u1eeba b\u1ec7nh truy\u1ec1n nhi\u1ec5m. M\u1ed9t trong nh\u1eefng h\u01b0\u1edbng ph\u00e1t tri\u1ec3n vaccine \u0111ang \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u v\u00e0 \u1ee9ng d\u1ee5ng m\u1ea1nh m\u1ebd hi\u1ec7n nay tr\u00ean th\u1ebf gi\u1edbi l\u00e0 s\u1eed d\u1ee5ng c\u00f4ng ngh\u1ec7 DNA t\u00e1i t\u1ed5 h\u1ee3p. Nhi\u1ec1u ch\u1ee7ng vi khu\u1ea9n t\u00e1i t\u1ed5 h\u1ee3p \u0111\u00e3 \u0111\u01b0\u1ee3c t\u1ea1o ra cho m\u1ee5c \u0111\u00edch tr\u00ean nh\u01b0 Escherichia coli, Vibrio cholerae, Listeria monocytogenes, … .Tuy nhi\u00ean, nh\u1eefng c\u00f4ng b\u1ed1 khoa h\u1ecdc d\u1ef1a tr\u00ean m\u00f4 h\u00ecnh n\u00e0y v\u1eabn c\u00f2n t\u1ed3n t\u1ea1i m\u1ed9t s\u1ed1 h\u1ea1n ch\u1ebf v\u1ec1 vi\u1ec7c bi\u1ec3u hi\u1ec7n v\u00e0 ki\u1ec3m so\u00e1t s\u1ef1 bi\u1ec3u hi\u1ec7n c\u00e1c protein m\u1ed9t c\u00e1ch ch\u1ee7 \u0111\u1ed9ng. H\u01b0\u1edbng nghi\u00ean c\u1ee9u ph\u00e1t tri\u1ec3n vaccine t\u1ea1i Trung t\u00e2m Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 sinh h\u1ecdc \u0111\u01b0\u1ee3c d\u1eabn d\u1eaft tr\u1ef1c ti\u1ebfp b\u1edfi PGS. TS. Nguy\u1ec5n \u0110\u1ee9c Ho\u00e0ng nh\u1eb1m \u1ee9ng d\u1ee5ng…xem th\u00eam.<\/a><\/span><\/p>\n

\"From<\/p>\n

X\u00e3 h\u1ed9i ng\u00e0y c\u00e0ng ph\u00e1t tri\u1ec3n, c\u00f4ng nghi\u1ec7p h\u00f3a l\u00e0m m\u00f4i tr\u01b0\u1eddng \u00f4 nhi\u1ec5m, \u00e1p l\u1ef1c c\u00f4ng vi\u1ec7c cao,\u2026 \u1ea3nh h\u01b0\u1edfng x\u1ea5u \u0111\u1ebfn s\u1ee9c kh\u1ecfe con ng\u01b0\u1eddi. B\u00ean c\u1ea1nh \u0111\u00f3, cu\u1ed9c s\u1ed1ng ng\u00e0y c\u00e0ng \u0111\u01b0\u1ee3c n\u00e2ng cao, con ng\u01b0\u1eddi c\u00e0ng quan t\u00e2m nhi\u1ec1u \u0111\u1ebfn s\u1ee9c kh\u1ecfe c\u1ee7a ch\u00ednh m\u00ecnh. Do \u0111\u00f3 ng\u01b0\u1eddi ti\u00eau d\u00f9ng r\u1ea5t quan t\u00e2m \u0111\u1ebfn nh\u1eefng s\u1ea3n ph\u1ea9m c\u00f3 ngu\u1ed3n g\u1ed1c t\u1ef1 nhi\u00ean, c\u00f3 ch\u1ee9a c\u00e1c h\u1ee3p ch\u1ea5t c\u00f3 ho\u1ea1t t\u00ednh t\u00ednh sinh h\u1ecdc nh\u01b0 kh\u00e1ng \u00f4xi h\u00f3a, kh\u00e1ng vi\u00eam, kh\u00e1ng ung th\u01b0.…xem th\u00eam.<\/a><\/span><\/p>\n

\"Applied<\/p>\n

<\/p>\n

Nh\u00f3m nghi\u00ean c\u1ee9u Tin sinh h\u1ecdc, thu\u1ed9c Trung t\u00e2m Khoa h\u1ecdc Sinh h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 Sinh h\u1ecdc, \u0111\u01b0\u1ee3c th\u00e0nh l\u1eadp t\u1eeb th\u00e1ng 10 n\u0103m 2012 v\u1edbi s\u1ef1 li\u00ean k\u1ebft c\u1ee7a c\u00e1c gi\u1ea3ng vi\u00ean, nghi\u00ean c\u1ee9u vi\u00ean t\u1eeb c\u00e1c khoa C\u00f4ng ngh\u1ec7 th\u00f4ng tin, khoa To\u00e1n-Tin, Khoa Sinh h\u1ecdc \u2013 C\u00f4ng ngh\u1ec7 sinh h\u1ecdc v\u00e0 PTN C\u00f4ng ngh\u1ec7 Sinh h\u1ecdc ph\u00e2n t\u1eed. Nh\u00f3m tuy\u1ec3n sinh vi\u00ean t\u1eeb 03 khoa trong Tr\u01b0\u1eddng: Khoa C\u00f4ng ngh\u1ec7 Th\u00f4ng tin, Khoa To\u00e1n v\u00e0 Khoa Sinh v\u00e0 C\u00f4ng ngh\u1ec7 Sinh h\u1ecdc. Nh\u00f3m nh\u1eadn t\u1eeb 3 \u0111\u1ebfn 5 sinh vi\u00ean m\u1ed7i n\u0103m th\u1ef1c hi\u1ec7n kh\u00f3a lu\u1eadn t\u1ed1t nghi\u1ec7p c\u1eed nh\u00e2n theo \u0111\u1ecbnh h\u01b0\u1edbng tin sinh h\u1ecdc. B\u00ean c\u1ea1nh sinh vi\u00ean \u0111\u1ea1i h\u1ecdc, nh\u00f3m c\u0169ng nh\u1eadn 1 \u0111\u1ebfn 2 h\u1ecdc vi\u00ean cao h\u1ecdc m\u1ed7i n\u0103m \u0111\u1ec3 th\u1ef1c hi\u1ec7n lu\u1eadn v\u0103n t\u1ed1t nghi\u1ec7p.….xem th\u00eam<\/a>.<\/p>\n

\"Bioinformatics<\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n

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<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

V\u1ec1 h\u01b0\u1edbng nghi\u00ean c\u1ee9u Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Khoa h\u1ecdc t\u1ef1 nhi\u00ean l\u00e0 n\u01a1i t\u1eadp trung c\u00e1c PTN v\u00e0 c\u00e1c B\u1ed9 m\u00f4n th\u1ef1c hi\u1ec7n c\u00e1c h\u01b0\u1edbng nghi\u00ean c\u1ee9u c\u01a1 b\u1ea3n v\u00e0 \u1ee9ng d\u1ee5ng kh\u00e1c nhau, n\u01a1i […]<\/p>","protected":false},"author":7,"featured_media":1004,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-templates\/fullwidth.php","meta":{"footnotes":""},"class_list":["post-1371","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/cbbiotec.vn\/en\/wp-json\/wp\/v2\/pages\/1371","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cbbiotec.vn\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cbbiotec.vn\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cbbiotec.vn\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/cbbiotec.vn\/en\/wp-json\/wp\/v2\/comments?post=1371"}],"version-history":[{"count":41,"href":"https:\/\/cbbiotec.vn\/en\/wp-json\/wp\/v2\/pages\/1371\/revisions"}],"predecessor-version":[{"id":2339,"href":"https:\/\/cbbiotec.vn\/en\/wp-json\/wp\/v2\/pages\/1371\/revisions\/2339"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cbbiotec.vn\/en\/wp-json\/wp\/v2\/media\/1004"}],"wp:attachment":[{"href":"https:\/\/cbbiotec.vn\/en\/wp-json\/wp\/v2\/media?parent=1371"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}